ABSTRACT
Patients with impaired glucose tolerance (IGT) are now considered as being pre-diabetic, which indicates their relatively high risk for developing diabetes mellitus associated with abnormal metabolic syndrome and cardiovascular diseases. However, dietary modification and physical exercise may play a critical role in this respect. To determine the influence of dietary modification and physical exercise in subjects with impaired glucose tolerance in Bangladesh, thirty three newly detected otherwise healthy subjects with IGT, aged 30-63 years, were randomly selected to participate in a 12 weeks diet and exercise program. Substantial improvement in glucose tolerance was observed at the end of 12 weeks particularly in middle aged subjects (41-50 years). Mean fasting blood glucose and 2 hr post load glucose value were reduced significantly. Glucose tolerance was reverted to normal in 66.7% of the participants, remained unchanged in 26.7% and deteriorated to diabetes in 6.7%. Significant reduction in serum total cholesterol, LDL cholesterol along with mild deterioration in HDL cholesterol and increase in triglyceride values were observed. It was found that the principles of 'prudent diet' in combination with physical exercise are highly effective in improving glucose tolerance, lowering total cholesterol and LDL cholesterol in IGT subjects.
ABSTRACT
This study was done to identify the lacking in conducting MBBS course-curriculum of Bangladesh. For this purpose a descriptive survey was done among 30 MBBS doctors (Passed within 10 years) of Faridpur district. No internship doctors were included. Self-administered unstructured questionnaire was supplied to them and qualitative analysis of data was done. Majority doctors dissatisfied with (i) Gaining knowledge and skill (ii) Environment of medical colleges (iii) Teaching method (iv) Less MCQ (v) Existing viva-voce (vi) Library facilities (vi) Less clinical symposium.
ABSTRACT
BACKGROUND & OBJECTIVES: Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Solanum trilobatum to treat hepatic diseases. Protective action of Solanum trilobatum extract (STE) was evaluated by us in an animal model of hepatotoxicity induced by carbon tetrachloride (CCl4). METHODS: Wistar albino rats were divided into five groups. Group I was normal control group; Group II, the hepatotoxic group was given CCl4; Groups III-V received different doses of plant extract with CCl(4). Liver marker enzymes were assayed in serum and antioxidant status was assessed in liver tissue. RESULTS: Levels of marker enzymes such as alanine transminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were increased significantly in CCl4 treated rats (group II). STE brought about a significant decrease in the activities of all these enzymes. Lipid peroxidation (LP) was increased significant in liver tissue in the CCl4 treated rats (group II) while the activities of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were decreased. STE treatment led to the recovery of these levels to near normal. INTERPRETATION & CONCLUSION: The present observations suggested that the treatment with S. trilobatum extract enhance the recovery from CCl4 induced hepatic damage due to its antioxidant and hepatoprotective property.